Anti-Human NRG1/Neuregulin-1 Reference Antibody (JK07, RUO) (HX096016)

Name: Anti-Human NRG1/Neuregulin-1 Reference Antibody (JK07, RUO)
Brand: abinScience
SKU: HX096016
Price: 370 USD
Availability: InStock

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概要

カタログ番号	HX096016
説明	Anti-Human NRG1/Neuregulin-1 (JK07) (HX096016) is a research-grade recombinant antibody targeting Glial growth factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	JK07
発現システム	Mammalian cells
ターゲット	Glial growth factor, Neu differentiation factor, SMDF, Breast cancer cell differentiation factor p45, Pro-neuregulin-1, membrane-bound isoform, Acetylcholine receptor-inducing activity, ARIA, GGF, HRGA, Pro-NRG1, HGL, HRG, NDF, NRG1, Sensory and motor neuron-derived factor, Heregulin
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q02297
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	JK07
背景	Pro-neuregulin-1, membrane-bound isoform (NRG1) is a ~70 kDa protein. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4. 1. Sweeney, C. et al. (2000) The Journal of biological chemistry 275, 19803-7. PMID: 10867024 2. Plowman, GD. et al. (1993) Nature 366, 473-5. PMID: 7902537 3. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778
注意事項	For research use only. Not suitable for clinical or therapeutic use.