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| カタログ番号 | HY504016 |
|---|---|
| 説明 |
Anti-Human PLA2G1B/PLA2 (DIACC 1010) (HY504016) is a research-grade recombinant antibody targeting Phospholipase A2. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | DIACC 1010 |
| 発現システム | Mammalian cells |
| ターゲット | Phospholipase A2, PLA2G1B, Group IB phospholipase A2, PLA2A, PPLA2, Phosphatidylcholine 2-acylhydrolase 1B, PLA2 |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P04054 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | DIACC-1010, DIACC1010, DIACC1010 |
| 背景 | Phospholipase A2 (PLA2G1B/PLA2) is a ~16 kDa protein. Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner. 1. Suzuki, N. et al. (2000) The Journal of biological chemistry 275, 5785-93. PMID: 10681567 2. Kanda, A. et al. (1992) Biochimica et biophysica acta 1171, 1-10. PMID: 1420353 3. Yu, BZ. et al. (2007) Biochimica et biophysica acta 1768, 2478-90. PMID: 17603006 4. Pan, Y. et al. (2014) Scientific reports 4, 6660. PMID: 25335547 5. Ancian, P. et al. (1995) The Journal of biological chemistry 270, 8963-70. PMID: 7721806 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human PLA2G1B/PLA2 (DIACC 1010)
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