Anti-Human PRAME Reference Antibody (GSK 2302032A, RUO) (HX996016)

Name: Anti-Human PRAME Reference Antibody (GSK 2302032A, RUO)
Brand: abinScience
SKU: HX996016
Price: 370 USD
Availability: InStock

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Numéro de catalogue	HX996016
Description	Anti-Human PRAME (GSK 2302032A) (HX996016) is a research-grade recombinant antibody targeting Opa-interacting protein 4. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	GSK 2302032A
Système d'expression	Mammalian cells
Nature	Recombinant
Cible	Opa-interacting protein 4, Preferentially expressed antigen of melanoma, MAPE, OIP-4, Melanoma antigen preferentially expressed in tumors, PRAME, OIP4
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P78395
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	GSK-2302032A, GSK2302032A, GSK2302032A
Contexte	Melanoma antigen preferentially expressed in tumors (PRAME) is a ~57 kDa protein. Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. 1. Costessi, A. et al. (2011) The EMBO journal 30, 3786-98. PMID: 21822215 2. Lin, HC. et al. (2015) Science (New York, N.Y.) 349, 91-5. PMID: 26138980 3. Epping, MT. et al. (2005) Cell 122, 835-47. PMID: 16179254
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human PRAME (GSK 2302032A)

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Anti-Human PRAME Reference Antibody (GSK 2302032A, RUO).pdf

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Anti-Human PRAME Reference Antibody (GSK 2302032A, RUO) (HX996016)

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