Anti-Human Nav1.7 Reference Antibody (Duke anti-Nav1.7, RUO) (HS929016)

Name: Anti-Human Nav1.7 Reference Antibody (Duke anti-Nav1.7, RUO)
Brand: abinScience
SKU: HS929016
Price: 176 USD
Availability: InStock

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Número de catálogo	HS929016
Descripción	Anti-Human SCN9A/Nav1.7 Antibody (Duke anti-NAv1.7) (HS929016) is a research-grade recombinant antibody targeting Sodium channel protein type 9 subunit alpha. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	Duke anti-Nav1.7
Sistema de expresión	Mammalian cells
Objetivo	Sodium channel protein type 9 subunit alpha, NENA, Neuroendocrine sodium channel, Sodium channel protein type IX subunit alpha, SCN9A, Voltage-gated sodium channel subunit alpha Nav1.7, PN1, Peripheral sodium channel 1, hNE-Na
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q15858
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Sodium channel protein type 9 subunit alpha (SCN9A/Nav1.7) is a ~226 kDa protein. Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain. 1. Cummins, TR. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8232-6. PMID: 15385606 2. Choi, JS. et al. (2006) Neurology 67, 1563-7. PMID: 16988069 3. Fertleman, CR. et al. (2006) Neuron 52, 767-74. PMID: 17145499 4. Cox, JJ. et al. (2006) Nature 444, 894-8. PMID: 17167479 5. Han, C. et al. (2009) Brain : a journal of neurology 132, 1711-22. PMID: 19369487 6. Eberhardt, M. et al. (2014) The Journal of biological chemistry 289, 1971-80. PMID: 24311784 7. Tan, ZY. et al. (2014) FEBS letters 588, 3964-9. PMID: 25240195 8. Ahuja, S. et al. (2015) Science (New York, N.Y.) 350, aac5464. PMID: 26680203 9. Klugbauer, N. et al. (1995) The EMBO journal 14, 1084-90. PMID: 7720699
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)