Anti-Human Nav1.7 Reference Antibody (Duke anti-Nav1.7, RUO) (HS929016)

Name: Anti-Human Nav1.7 Reference Antibody (Duke anti-Nav1.7, RUO)
Brand: abinScience
SKU: HS929016
Price: 176 USD
Availability: InStock

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概要
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参考文献
データシート
SDS

概要

カタログ番号	HS929016
説明	Anti-Human SCN9A/Nav1.7 Antibody (Duke anti-NAv1.7) (HS929016) is a research-grade recombinant antibody targeting Sodium channel protein type 9 subunit alpha. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	Duke anti-Nav1.7
発現システム	Mammalian cells
ターゲット	Sodium channel protein type 9 subunit alpha, NENA, Neuroendocrine sodium channel, Sodium channel protein type IX subunit alpha, SCN9A, Voltage-gated sodium channel subunit alpha Nav1.7, PN1, Peripheral sodium channel 1, hNE-Na
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q15858
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Sodium channel protein type 9 subunit alpha (SCN9A/Nav1.7) is a ~226 kDa protein. Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain. 1. Cummins, TR. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8232-6. PMID: 15385606 2. Choi, JS. et al. (2006) Neurology 67, 1563-7. PMID: 16988069 3. Fertleman, CR. et al. (2006) Neuron 52, 767-74. PMID: 17145499 4. Cox, JJ. et al. (2006) Nature 444, 894-8. PMID: 17167479 5. Han, C. et al. (2009) Brain : a journal of neurology 132, 1711-22. PMID: 19369487 6. Eberhardt, M. et al. (2014) The Journal of biological chemistry 289, 1971-80. PMID: 24311784 7. Tan, ZY. et al. (2014) FEBS letters 588, 3964-9. PMID: 25240195 8. Ahuja, S. et al. (2015) Science (New York, N.Y.) 350, aac5464. PMID: 26680203 9. Klugbauer, N. et al. (1995) The EMBO journal 14, 1084-90. PMID: 7720699
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)