Anti-Human Siglec-10 Reference Antibody (ONC-841, RUO) (HV244016)

Name: Anti-Human Siglec-10 Reference Antibody (ONC-841, RUO)
Brand: abinScience
SKU: HV244016
Price: 176 USD
Availability: InStock

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概要

カタログ番号	HV244016
説明	Anti-Human SIGLEC10/SLG2 Antibody (ONC-841) (HV244016) is a research-grade recombinant antibody targeting SIGLEC10. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG4, kappa
クローンID	ONC-841
発現システム	Mammalian cells
ターゲット	SIGLEC10, Siglec-10, Sialic acid-binding Ig-like lectin 10, Siglec-like protein 2, SLG2
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q96LC7
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Sialic acid-binding Ig-like lectin 10 (SIGLEC10/SLG2) is a ~76 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling. 1. Munday, J. et al. (2001) The Biochemical journal 355, 489-97. PMID: 11284738 2. Kitzig, F. et al. (2002) Biochemical and biophysical research communications 296, 355-62. PMID: 12163025 3. Zhang, P. et al. (2015) The Journal of surgical research 194, 107-13. PMID: 25450598
注意事項	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human SIGLEC10/SLG2 Antibody (ONC-841)

参考文献

データシート

Anti-Human Siglec-10 Reference Antibody (ONC-841, RUO).pdf

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Anti-Human Siglec-10 Reference Antibody (ONC-841, RUO) (HV244016)

概要

イメージ

参考文献

データシート

SDS

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