Anti-Human Siglec-10 Reference Antibody (ONC-841, RUO) (HV244016)

Name: Anti-Human Siglec-10 Reference Antibody (ONC-841, RUO)
Brand: abinScience
SKU: HV244016
Price: 176 USD
Availability: InStock

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Обзор

Каталожный номер	HV244016
Описание	Anti-Human SIGLEC10/SLG2 Antibody (ONC-841) (HV244016) is a research-grade recombinant antibody targeting SIGLEC10. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG4, kappa
ID клона	ONC-841
Система экспрессии	Mammalian cells
Цель	SIGLEC10, Siglec-10, Sialic acid-binding Ig-like lectin 10, Siglec-like protein 2, SLG2
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q96LC7
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Sialic acid-binding Ig-like lectin 10 (SIGLEC10/SLG2) is a ~76 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling. 1. Munday, J. et al. (2001) The Biochemical journal 355, 489-97. PMID: 11284738 2. Kitzig, F. et al. (2002) Biochemical and biophysical research communications 296, 355-62. PMID: 12163025 3. Zhang, P. et al. (2015) The Journal of surgical research 194, 107-13. PMID: 25450598
Примечание	For research use only. Not suitable for clinical or therapeutic use.

Изображения

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human SIGLEC10/SLG2 Antibody (ONC-841)

Ссылки

Даташит

Anti-Human Siglec-10 Reference Antibody (ONC-841, RUO).pdf

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