Anti-Human alpha-Synuclein Reference Antibody (Lu AF82422, RUO) (HW755086)

Name: Anti-Human alpha-Synuclein Reference Antibody (Lu AF82422, RUO)
Brand: abinScience
SKU: HW755086
Price: 176 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HW755086
説明	Anti-Human SNCA/Alpha-synuclein (Lu AF82422) (HW755086) is a research-grade recombinant antibody targeting Alpha-synuclein. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1
クローンID	Lu AF82422
発現システム	Mammalian cells
テスト済みアプリケーション	WB
ターゲット	Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P37840
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	LuAF82422
背景	Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. 1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282 2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590 3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128 4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

イメージ

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human SNCA/Alpha-synuclein (Lu AF82422).
Western blot

Western blot analysis was performed using anti-SNCA monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human SNCA (Catalog No: HW755012)
Lane 2: negative control
Bioactivity

Detects recombinant human SNCA (Catalog No: HW755012) in indirect ELISA