Anti-Human STAT3 Reference Antibody (SBT-100, RUO) (HW708016)

Name: Anti-Human STAT3 Reference Antibody (SBT-100, RUO)
Brand: abinScience
SKU: HW708016
Price: 326 USD
Availability: InStock

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100ug
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概要
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参考文献
データシート
SDS

概要

カタログ番号	HW708016
説明	Anti-Human STAT3 (SBT-100) (HW708016) is a research-grade recombinant antibody targeting Signal transducer and activator of transcription 3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Alpaca
クローン性	Monoclonal
アイソタイプ	VHH-His
クローンID	SBT-100
発現システム	Mammalian cells
ターゲット	Signal transducer and activator of transcription 3, APRF, STAT3, Acute-phase response factor
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Purified by Nickel column.
アクセッション番号	P40763
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	SBT-100, SBT100, SBT100
背景	Signal transducer and activator of transcription 3 (STAT3) is a ~88 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. 1. Tsai, YT. et al. (2000) Molecular and cellular biology 20, 2043-54. PMID: 10688651 2. Yamamoto, T. et al. (2002) Biochemical and biophysical research communications 297, 811-7. PMID: 12359225 3. Shao, H. et al. (2003) Cancer research 63, 3923-30. PMID: 12873986 4. Dreuw, A. et al. (2004) The Journal of biological chemistry 279, 36112-20. PMID: 15194700 5. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 15653507 6. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960 7. Saxena, NK. et al. (2007) The Journal of biological chemistry 282, 13316-25. PMID: 17344214 8. Jiang, H. et al. (2008) Biochemical and biophysical research communications 368, 1-5. PMID: 18242580 9. Hou, T. et al. (2008) The Journal of biological chemistry 283, 30725-34. PMID: 18782771 10. Gao, X. et al. (2012) Molecular cell 45, 598-609. PMID: 22306293
注意事項	For research use only. Not suitable for clinical or therapeutic use.