Anti-Human TERM2 Reference Antibody (VHB937, RUO) (HV166086)

Name: Anti-Human TERM2 Reference Antibody (VHB937, RUO)
Brand: abinScience
SKU: HV166086
Price: 176 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HV166086

Descripción

Anti-Human TERM2 Antibody (VHB937) (HV166086) is a research-grade recombinant antibody targeting TREM-2.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.

Reactividad de especies

Human

Aplicaciones

ELISA, FACS, Functional assay

Especie huésped

Human

Clonalidad

Monoclonal

Isotipo

IgG1, kappa

ID de clon

VHB937

Objetivo

TREM-2, TREM2, Triggering receptor expressed on monocytes 2, Triggering receptor expressed on myeloid cells 2

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q9NZC2

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Triggering receptor expressed on myeloid cells 2 (TERM2) is a ~25 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin.

1. Bouchon, A. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4991-5. PMID: 10799849

2. Yeh, FL. et al. (2016) Neuron 91, 328-40. PMID: 27477018

3. Zhao, Y. et al. (2018) Neuron 97, 1023-1031.e7. PMID: 29518356

4. Sudom, A. et al. (2018) The Journal of biological chemistry 293, 12634-12646. PMID: 29794134

5. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881

6. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066

7. Bouchon, A. et al. (2001) The Journal of experimental medicine 194, 1111-22. PMID: 11602640

8. Paloneva, J. et al. (2003) The Journal of experimental medicine 198, 669-75. PMID: 12925681

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human TERM2 Antibody (VHB937)

Referencias

Datasheet

Anti-Human TERM2 Reference Antibody (VHB937, RUO).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo