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| カタログ番号 | HB274036 |
|---|---|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | ST2485 |
| 生物学的活性 | as well as in a xenograft model. ST2485 binds human tenascin at an epitope partially shared with BC2. ST2485 cross-reacts with murine tenascin. ST2485 can be studied in antitumor research [1]. |
| 発現システム | Mammalian cells |
| ターゲット | Myotendinous antigen, Neuronectin, GMEM, Tenascin, Tenascin-C, TN-C, TNC, TN, Cytotactin, GP 150-225, Glioma-associated-extracellular matrix antigen, HXB, Hexabrachion, JI |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P24821 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ST2485 |
| 背景 | Tenascin (Tenascin-C/TNC) is a ~240 kDa protein. Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. 1. Martina, E. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 778-87. PMID: 19884327 |
| 参考文献 | 1. Petronzelli, F., et al., (2005). Improved tumor targeting by combined use of two antitenascin antibodies. Clinical cancer research: an official journal of the American Association for Cancer Research, 11(19 Pt 2), 7137s–7145s. [HB274036] |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human TNC (ST2485)
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