Anti-pan-Ebolavirus Glycoprotein Reference Antibody (ADI-15878, RUO) (VK623106)

Name: Anti-pan-Ebolavirus Glycoprotein Reference Antibody (ADI-15878, RUO)
Brand: abinScience
SKU: VK623106
Price: 176 USD
Availability: InStock

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Каталожный номер	VK623106
Описание	Anti-REBOV/SEBOV/TAFV/ZEBOV GP/Envelope glycoprotein Antibody (ADI-15878) (VK623106) is a research-grade recombinant antibody targeting Envelope glycoprotein. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Zaire ebolavirus (ZEBOV) (Zaire Ebola virus), Bundibugyo virus (BDBV), Sudan ebolavirus (SEBOV) (Sudan Ebola virus), Tai Forest ebolavirus (TAFV) (Cote d'Ivoire Ebola virus), Reston ebolavirus (REBOV) (Reston Ebola virus)
Применения	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1-kappa
ID клона	ADI-15878
Цель	Envelope glycoprotein, GP, GP1, GP1,2, GP1,2-delta, GP2, Shed GP
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q05320
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity) (Probable). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes. 1. Simmons, G. et al. (2002) Journal of virology 76, 2518-28. PMID: 11836430 2. Takada, A. et al. (2000) Virology 278, 20-6. PMID: 11112476 3. Iampietro, M. et al. (2017) PLoS pathogens 13, e1006397. PMID: 28542576 4. Edri, A. et al. (2018) Frontiers in immunology 9, 1428. PMID: 30013549 5. Vande Burgt, NH. et al. (2015) Viruses 7, 5587-602. PMID: 26516900 6. Brinkmann, C. et al. (2016) Journal of virology 90, 11075-11086. PMID: 27707924 7. González-Hernández, M. et al. (2018) Journal of virology 92. PMID: 29669839 8. Rizk, MG. et al. (2017) Journal of virology 91. PMID: 28878074
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Изображения

Bioactivity

Research Grade Anti-REBOV/SEBOV/TAFV/ZEBOV GP/Envelope glycoprotein Antibody (ADI-15878) (DVV03610)
SDS-PAGE

SDS-PAGE for Anti-REBOV/SEBOV/TAFV/ZEBOV GP/Envelope glycoprotein Reference Antibody (ADI-15878, RUO)