Anti-HRSV Post-Fusion Glycoprotein Reference Antibody (ADI-14359, RUO) (VK421116)

Name: Anti-HRSV Post-Fusion Glycoprotein Reference Antibody (ADI-14359, RUO)
Brand: abinScience
SKU: VK421116
Price: 370 USD
Availability: InStock

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Каталожный номер	VK421116
Реактивность видов	Human respiratory syncytial virus A (HRSV-A)
Применения	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	ADI-14359
Биологическая активность	ADI-14359 binds to epitope I of RSV postF via convergent CDR H3 motifs and germline-encoded features of its IGKV1-39 light chain and IGHV2-70 heavy chain, with key interactions mediated by specific hydrogen bonds and electrostatic contacts [1]. ADI-14359 (6.25 nM-1600 nM) binds to RSV postF with a K D value of 387 nM; the heavy chain Arg50 residue and postF Lys390 residue are critical for this interaction, as disruption of these residues significantly reduces or even completely abolishes binding [1]. ADI-14359 recognizes antigenic epitope I on RSV F, preferentially binds to the post-fusion conformation, and does not neutralize RSV [1].
Цель	F, F1, F2, Fusion glycoprotein F0, Fusion glycoprotein F1, Fusion glycoprotein F2, Intervening segment, Pep27, Peptide 27, p27
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P03420, P11209, 12568, O36634, P13843
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	ADI-14359
Фон	Fusion glycoprotein F0 is a ~63 kDa protein. Inactive precursor that is cleaved at two sites by a furin-like protease to give rise to the mature F1 and F2 fusion glycoproteins.
Ссылки	1. Goodwin E, et al. Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity. 2018;48(2):339-349.e5. [VK421116]
Примечание	For research use only. Not suitable for clinical or therapeutic use.