Anti-Human Claudin-18.2 Reference Antibody (Arcotatug, RUO) (HX126296)

Name: Anti-Human Claudin-18.2 Reference Antibody (Arcotatug, RUO)
Brand: abinScience
SKU: HX126296
Price: 176 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HX126296
説明	arcotatug (HX126296) is a research-grade recombinant antibody targeting CLDN18.2. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
種反応性	Human
アプリケーション	ELISA, FCM, Functional assay
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
ターゲット	CLDN18.2, Claudin-18.2
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P56856-2
形態	Liquid
保存バッファー	0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	CAS: 3031170-61-0
背景	Claudin-18 is a ~27 kDa protein. Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling. Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier. Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription. Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency. Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways.
注意事項	For research use only.