Anti-Human ALK-1 Reference Antibody (Ascrinvacumab, RUO) (HW651016)

Name: Anti-Human ALK-1 Reference Antibody (Ascrinvacumab, RUO)
Brand: abinScience
SKU: HW651016
Price: 176 USD
Availability: InStock

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100ug
1mg
5mg
10mg
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50mg
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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HW651016

Description

Ascrinvacumab (HW651016) is a research-grade recombinant antibody targeting Serine/threonine-protein kinase receptor R3. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Reactivité des espèces

Human

Applications

ELISA, WB, Bioactivity: FACS, Functional assay, Research in vivo

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG2-kappa

Système d'expression

Mammalian cells

Applications testées

Cible

Serine/threonine-protein kinase receptor R3, ACVRL1, Activin receptor-like kinase 1, ALK-1, ACVRLK1, ALK1, SKR3, TGF-B superfamily receptor type I, TSR-I

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P37023

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Noms alternatifs

PF-03446962, 1463459-96-2

Contexte

Activin receptor type-1-like (ACVRL1/ALK-1) is a ~56 kDa protein. Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Note

For research use only. Not suitable for clinical or therapeutic use.

Isotype Control

Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10) (HV988107)

Images

SEC-HPLC

SEC-HPLC detection for Research Grade Ascrinvacumab.
Bioactivity

Detects ACVRL1/ALK-1 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Anti-Human ALK-1 Reference Antibody (Ascrinvacumab, RUO)
Western blot

Western blot analysis was performed using anti-ACVRL1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human ACVRL1 (Catalog No: HW651011)
Lane 2: negative control