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| カタログ番号 | HW651016 | ||||||
|---|---|---|---|---|---|---|---|
| 説明 |
Ascrinvacumab (HW651016) is a research-grade recombinant antibody targeting Serine/threonine-protein kinase receptor R3. Produced in mammalian cells with native-like glycosylation.
Highlights
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| 種反応性 | Human | ||||||
| アプリケーション | ELISA, WB, Bioactivity: FACS, Functional assay, Research in vivo | ||||||
| 宿主種 | Human | ||||||
| クローン性 | Monoclonal | ||||||
| アイソタイプ | IgG2-kappa | ||||||
| 発現システム | Mammalian cells | ||||||
| テスト済みアプリケーション | WB | ||||||
| ターゲット | Serine/threonine-protein kinase receptor R3, ACVRL1, Activin receptor-like kinase 1, ALK-1, ACVRLK1, ALK1, SKR3, TGF-B superfamily receptor type I, TSR-I | ||||||
| エンドトキシンレベル | < 10 EU/mg | ||||||
| 純度 | >95% purity as determined by SDS-PAGE. | ||||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||||
| アクセッション番号 | P37023 | ||||||
| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 別名 | PF-03446962, 1463459-96-2 | ||||||
| 背景 | Activin receptor type-1-like (ACVRL1/ALK-1) is a ~56 kDa protein. Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. | ||||||
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. | ||||||
| Isotype Control | Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10) (HV988107) |
SEC-HPLC detection for Research Grade Ascrinvacumab.
Detects ACVRL1/ALK-1 in indirect ELISAs.
SDS-PAGE for Anti-Human ALK-1 Reference Antibody (Ascrinvacumab, RUO)
Western blot analysis was performed using anti-ACVRL1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human ACVRL1 (Catalog No: HW651011)
Lane 2: negative control
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