







| Каталожный номер | HW651016 | ||||||
|---|---|---|---|---|---|---|---|
| Описание |
Ascrinvacumab (HW651016) is a research-grade recombinant antibody targeting Serine/threonine-protein kinase receptor R3. Produced in mammalian cells with native-like glycosylation.
Highlights
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| Реактивность видов | Human | ||||||
| Применения | ELISA, WB, Bioactivity: FACS, Functional assay, Research in vivo | ||||||
| Хозяинский вид | Human | ||||||
| Клоональность | Monoclonal | ||||||
| Изотип | IgG2-kappa | ||||||
| Система экспрессии | Mammalian cells | ||||||
| Проверенные приложения | WB | ||||||
| Цель | Serine/threonine-protein kinase receptor R3, ACVRL1, Activin receptor-like kinase 1, ALK-1, ACVRLK1, ALK1, SKR3, TGF-B superfamily receptor type I, TSR-I | ||||||
| Уровень эндотоксинов | < 10 EU/mg | ||||||
| Чистота | >95% purity as determined by SDS-PAGE. | ||||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||||
| Номер доступа | P37023 | ||||||
| Форма | Liquid | ||||||
| Буфер хранения | 0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| Альтернативные названия | PF-03446962, 1463459-96-2 | ||||||
| Фон | Activin receptor type-1-like (ACVRL1/ALK-1) is a ~56 kDa protein. Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. | ||||||
| Примечание | For research use only. Not suitable for clinical or therapeutic use. | ||||||
| Isotype Control | Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10) (HV988107) |

SEC-HPLC detection for Research Grade Ascrinvacumab.

Detects ACVRL1/ALK-1 in indirect ELISAs.

SDS-PAGE for Anti-Human ALK-1 Reference Antibody (Ascrinvacumab, RUO)

Western blot analysis was performed using anti-ACVRL1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human ACVRL1 (Catalog No: HW651011)
Lane 2: negative control




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