Anti-Human ST2/IL-33R Reference Antibody (Astegolimab, RUO) (MX139016)

Name: Anti-Human ST2/IL-33R Reference Antibody (Astegolimab, RUO)
Brand: abinScience
SKU: MX139016
Price: 346 USD
Availability: InStock

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Aperçu

Numéro de catalogue	MX139016
Description	Astegolimab (MX139016) is a research-grade recombinant antibody targeting T1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a-kappa
Système d'expression	Mammalian cells
Applications testées	WB
Cible	T1, DER4, Interleukin-1 receptor-like 1, ST2, IL1RL1, Protein ST2
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q01638
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	AMG-282, MSTT-1041A, RG-6149, RO-7187807, 2173054-79-8
Contexte	Interleukin-1 receptor-like 1 (IL1RL1/ST2) is a ~63 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. 1. Yi, XM. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2116279119. PMID: 35238669 2. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016
Note	For research use only.
Isotype Control	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507)

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SDS-PAGE

SDS-PAGE for Research Grade Astegolimab
Bioactivity

Detects recombinant human IL1RL1/ST2 (Catalog No: HX139011) in indirect ELISA
Western blot

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: ATGE3660 200ng
Lane 2: 1* loading buffer