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| カタログ番号 | CF909016 | ||||
|---|---|---|---|---|---|
| 説明 |
Bedinvetmab (CF909016) is a research-grade recombinant antibody targeting NGF/Beta-NGF. Produced in mammalian cells with native-like glycosylation.
Highlights
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| 種反応性 | Canine | ||||
| アプリケーション | ELISA, Bioactivity: FCM, Functional assay, Research in vivo | ||||
| 宿主種 | Canine | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2, lambda | ||||
| ターゲット | Beta-NGF, Beta-nerve growth factor, NGF, NGFB | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | F1PDQ3 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 別名 | ZTS-00508841, 2171034-69-6 | ||||
| 背景 | Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs. • Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair., PMID:37284244 • New insights of the role of β-NGF in the ovulation mechanism of induced ovulating species., PMID:30763273 • Effect of the Camelid's Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis., PMID:28713816 • β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis., PMID:28253191 • The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19., PMID:35095908 • HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy., PMID:38646645 • Heterologous beta-nerve growth factor (β-NGF) given at the LH surge enhances luteal function in dairy heifers., PMID:34186420 • β-NGF Stimulates Steroidogenic Enzyme and VEGFA Gene Expression, and Progesterone Secretion via ERK 1/2 Pathway in Primary Culture of Llama Granulosa Cells., PMID:33195615 • Ovulation mechanism in South American Camelids: The active role of β-NGF as the chemical signal eliciting ovulation in llamas and alpacas., PMID:32088046 • Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway., PMID:33179111 | ||||
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
Detects Canine NGF in indirect ELISA.
SDS-PAGE for Anti-Human beta-NGF Reference Antibody (Bedinvetmab, RUO)
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