Anti-Human BCMA/TNFRSF17 Reference Antibody (Belantamab, RUO) (HX959016)

Name: Anti-Human BCMA/TNFRSF17 Reference Antibody (Belantamab, RUO)
Brand: abinScience
SKU: HX959016
Price: 176 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HX959016
Description	Belantamab (HX959016) is a research-grade recombinant antibody targeting CD269. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-kappa
Applications testées	WB, FCM
Cible	B-cell maturation protein, BCM, BCMA, CD269, TNFRSF17, Tumor necrosis factor receptor superfamily member 17
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q02223
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	BCMA, 2857916, GSK2857916, J6M0, J6M0-mcMMAF, 2061894-48-0
Contexte	Tumor necrosis factor receptor superfamily member 17 (CD269/BCMA) is a ~20 kDa protein. Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. CD269 is the therapeutic target of teclistamab (Tecvayli).
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SEC-HPLC

SEC-HPLC detection for Research Grade Belantamab.
Bioactivity

Detects CD269/TNFRSF17/BCMA in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Anti-Human BCMA/TNFRSF17 Reference Antibody (Belantamab, RUO)
Flow CytoMetry

Flow-cytometry using anti-human CD269 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human CD269 monoclonal antibody (Catalog: HX959016) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Western blot

Western blot analysis was performed using anti-CD269 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD269 (Catalog No: HX959011)
Lane 2: negative control