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| カタログ番号 | YP489016 | ||||
|---|---|---|---|---|---|
| 説明 |
Bentracimab (YP489016) is a research-grade recombinant antibody targeting Ticagrelor. Produced in mammalian cells with native-like glycosylation.
Highlights
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| 種反応性 | General | ||||
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | Fab-G1-lambda | ||||
| クローンID | Bentracimab | ||||
| 発現システム | Mammalian cells | ||||
| ターゲット | Ticagrelor | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% purity as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | CAS: 274693-27-5 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 別名 | MEDI2452, anti-ticagrelor, antidote for ticagrelor, CAS: 274693-27-5 | ||||
| 背景 | Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor. • Ticagrelor., PMID:35396017 • Ticagrelor with or without Aspirin in High-Risk Patients after PCI., PMID:31556978 • Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Patient-Level Meta-Analysis., PMID:38506796 • Ticagrelor: clinical development and future potential., PMID:34258905 • Ticagrelor resistance: a case series and algorithm for management of non-responders., PMID:34215660 • Is ticagrelor worth its high cost and side-effects?, PMID:29730968 • Ticagrelor in stable coronary disease., PMID:37586825 • Ticagrelor-Associated Urticaria., PMID:35639409 • Ticagrelor Use in Stroke Patients: Past, Present, and Future., PMID:34163168 • Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial., PMID:32334703 | ||||
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Bentracimab
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