Anti-Human Transferrin R/TfR Reference Antibody (Delpacibart, RUO) (HY036036)

Name: Anti-Human Transferrin R/TfR Reference Antibody (Delpacibart, RUO)
Brand: abinScience
SKU: HY036036
Price: 176 USD
Availability: InStock

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Vista general

Número de catálogo	HY036036
Descripción	Delpacibart (HY036036) is a research-grade recombinant antibody targeting CD71. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-kappa
Aplicaciones probadas	WB
Objetivo	CD71, T9, TFRC, TR, TfR, TfR1, Transferrin receptor 1, Transferrin receptor protein 1, Transferrin receptor protein 1, serum form, Trfr, p90, sTfR
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P02786
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	2653183-68-5, 2653183-66-3
Fondo	Transferrin receptor protein 1 (CD71/TFRC) is a ~84 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. 1. Senyilmaz, D. et al. (2015) Nature 525, 124-8. PMID: 26214738 2. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 26642240
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Imágenes

Bioactivity

Detects Recombinant Human CD71/TFRC Protein, C-His (Cat No.: HY036011) in indirect ELISA.
Western blot

Western blot analysis was performed using anti-CD71/TFRC monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD71/TFRC (Catalog No: HY036011)
Lane 2: negative control
SDS-PAGE

SDS-PAGE for Anti-Human Transferrin R/TfR Reference Antibody (Delpacibart, RUO)