Anti-Human Coagulation Factor IX&Coagulation Factor X Reference Antibody (Denecimig, RUO) (HF610026)

Name: Anti-Human Coagulation Factor IX&Coagulation Factor X Reference Antibody (Denecimig, RUO)
Brand: abinScience
SKU: HF610026
Price: 176 USD
Availability: InStock

Даташит Поделиться продуктом Копировать информацию

Цена(USD):

Спецификация:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

Количество:

Свяжитесь с нами

Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HF610026
Описание	Denecimig (HF610026) is a research-grade recombinant antibody targeting Stuart factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG4-kappa
Система экспрессии	Mammalian cells
Цель	Stuart factor, Stuart-Prower factor, Coagulation factor X, F10, Plasma thromboplastin component, F9, Christmas factor, Coagulation factor IX, PTC
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P00742, P00740
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	2488745-86-2
Фон	Coagulation factor X (F10/Factor X & F9) is a ~54 kDa protein. Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner. Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1/F2R-dependent manner. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues. 1. Manithody, C. et al. (2012) Biochemistry 51, 2551-7. PMID: 22409427 2. Cao, Q. et al. (2025) Nature 639, 816-824. PMID: 39880037 3. Bukowska, A. et al. (2013) European journal of pharmacology 718, 114-23. PMID: 24041930 4. Shinozawa, E. et al. (2018) Frontiers in pharmacology 9, 1431. PMID: 30568593 5. D'Alessandro, E. et al. (2021) Cells 10. PMID: 34831181 6. Borensztajn, K. et al. (2008) The American journal of pathology 172, 309-20. PMID: 18202198 7. Shrivastava, G. et al. (2022) ImmunoHorizons 6, 373-383. PMID: 35738824 8. Senden, NH. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 4318-24. PMID: 9780208
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)

Изображения

Flow cytometry

Hela cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human F9 monoclonal antibody (Catalog HF610026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analyzed on a NovoCyte Flow Cytometer.
Flow cytometry

A549 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human F10 monoclonal antibody (Catalog HF610026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analyzed on a NovoCyte Flow Cytometer.
SDS-PAGE

SDS-PAGE for Anti-Human Coagulation Factor IX&Coagulation Factor X Reference Antibody (Denecimig, RUO)

Ссылки

Даташит

Anti-Human Coagulation Factor IX&Coagulation Factor X Reference Antibody (Denecimig, RUO).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа