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Anti-Human Sialidase-2 Reference Antibody (Efgitasialase Alfa, RUO) (HA532016)

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Vista general
Número de catálogoHA532016
Descripción
efgitasialase alfa (HA532016) is a research-grade recombinant antibody targeting sialidase-2.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
Reactividad de especiesHuman
AplicacionesELISA, Functional assay, Research in vivo
ClonalidadMonoclonal
Sistema de expresión Mammalian cells
Naturaleza Recombinant
Objetivo sialidase-2
Nivel de endotoxinas < 10 EU/mg as determined by LAL method.
Pureza >95% as determined by SDS-PAGE.
Número de acceso Q9Y3R4
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Envío In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos2891502-37-5
Fondo

Sialidase-2 is a ~42 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages.

1. Tringali, C. et al. (2004) The Journal of biological chemistry 279, 3169-79. PMID: 14613940
2. Mozzi, A. et al. (2012) Proteins 80, 1123-32. PMID: 22228546
Nota For research use only. Not suitable for clinical or therapeutic use.
Imágenes
Referencias
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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