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Anti-Human Sialidase-2 Reference Antibody (Efgitasialase Alfa, RUO) (HA532016)

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Aperçu
Numéro de catalogueHA532016
Description
efgitasialase alfa (HA532016) is a research-grade recombinant antibody targeting sialidase-2.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
Reactivité des espècesHuman
ApplicationsELISA, Functional assay, Research in vivo
ClonalitéMonoclonal
Système d'expression Mammalian cells
Nature Recombinant
Cible sialidase-2
Niveau d'endotoxines < 10 EU/mg as determined by LAL method.
Pureté >95% as determined by SDS-PAGE.
Numéro d'accès Q9Y3R4
Forme Liquid
Tampon de stockage 0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Expédition In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs2891502-37-5
Contexte

Sialidase-2 is a ~42 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages.

1. Tringali, C. et al. (2004) The Journal of biological chemistry 279, 3169-79. PMID: 14613940
2. Mozzi, A. et al. (2012) Proteins 80, 1123-32. PMID: 22228546
Note For research use only. Not suitable for clinical or therapeutic use.
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Reférences
Fiche technique
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human Sialidase-2 Reference Antibody (Efgitasialase Alfa, RUO)

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