Research Grade Efpegerglucagon (HF737016)

Name: Research Grade Efpegerglucagon
Brand: abinScience
SKU: HF737016
Price: 424 USD
Availability: InStock

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Обзор

Каталожный номер	HF737016
Реактивность видов	Human
Применения	ELISA, Functional assay, Research in vivo
Изотип	Synthetic glucagon peptide analogue conjugated with human IgG4 Fc fragment
Биологическая активность	GLP-1 (7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats [2]. Infusion of GLP-1 (7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM [2].
Система экспрессии	Mammalian cells
Цель	GLP-1(7-36), Incretin hormone, GLP-2, GCG, GLP-1(7-37), OXM, Pro-glucagon, GLP-1, GRPP, OXY
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P01275
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	2766774-81-4
Фон	Pro-glucagon (GCG) is a ~20 kDa protein. Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Binds to and activates the glucagon receptor GCGR, which couples to the G(s) G protein and elevates intracellular cAMP, triggering downstream metabolic responses. 1. Qiao, A. et al. (2020) Science (New York, N.Y.) 367, 1346-1352. PMID: 32193322
Ссылки	1. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004). [HF737016] 2. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7. [HF737016]
Примечание	For research use only. Not suitable for clinical or therapeutic use.

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Research Grade Efpegerglucagon.pdf

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