Anti-Human IGF-I R/IGF1R Reference Antibody (Elegrobart, RUO) (HY353156)

Name: Anti-Human IGF-I R/IGF1R Reference Antibody (Elegrobart, RUO)
Brand: abinScience
SKU: HY353156
Price: 176 USD
Availability: InStock

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概要

カタログ番号	HY353156
説明	elegrobart (HY353156) is a research-grade recombinant antibody targeting CD221. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1, Kappa
種	Human
ターゲット	CD221/IGF1R
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
アクセッション番号	P08069
形態	Liquid
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	2832924-76-0
背景	Insulin-like growth factor 1 receptor (CD221/IGF1R) is a ~154 kDa protein. Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins.
注意事項	For research use only. Not suitable for clinical or therapeutic use.