Anti-Human M-CSF R/CD115 Reference Antibody (Emactuzumab, RUO) (HY035026)

Name: Anti-Human M-CSF R/CD115 Reference Antibody (Emactuzumab, RUO)
Brand: abinScience
SKU: HY035026
Price: 176 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HY035026
説明	Emactuzumab (HY035026) is a research-grade recombinant antibody targeting CD115. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1-kappa
発現システム	Mammalian cells
テスト済みアプリケーション	FCM
ターゲット	CD115, CSF-1 receptor, CSF1R, M-CSF-R, CSF-1-R, Proto-oncogene c-Fms, Macrophage colony-stimulating factor 1 receptor, CSF-1R, FMS
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P07333
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	RG7155, RO5509554, 1448221-67-7
背景	Macrophage colony-stimulating factor 1 receptor (CD115/CSF1R) is a ~107 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. 1. Wei, S. et al. (2010) Journal of leukocyte biology 88, 495-505. PMID: 20504948 2. Guo, L. et al. (2019) American journal of human genetics 104, 925-935. PMID: 30982609 3. Oosterhof, N. et al. (2019) American journal of human genetics 104, 936-947. PMID: 30982608
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (E356D/M358L), kappa Recombinant Isotype Control Antibody (HyHEL-10) (HV080013)

イメージ

Bioactivity

Detects CD115/CSF1R in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Emactuzumab.
Flow CytoMetry

Flow-cytometry using PE anti-human CD115 antibody. THP-1 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD115 monoclonal antibody (Catalog: HY035026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.