Anti-Human IFN-gamma Reference Antibody (Emapalumab, RUO) (HF813016)

Name: Anti-Human IFN-gamma Reference Antibody (Emapalumab, RUO)
Brand: abinScience
SKU: HF813016
Price: 176 USD
Availability: InStock

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100ug
1mg
5mg
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50mg
100mg

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Vista general

Número de catálogo	HF813016
Descripción	Emapalumab (HF813016) is a research-grade recombinant antibody targeting Interferon gamma. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-lambda
Sistema de expresión	Mammalian cells
Aplicaciones probadas	WB
Objetivo	Interferon gamma, IFN-gamma, Immune interferon, IFNG
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P01579
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	NI-0501, emapalumab-lzsg, 1709815-23-5
Fondo	Interferon gamma (IFNG/IFN-gamma) is a ~19 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. 1. El Bougrini, J. et al. (2006) Cellular and molecular biology (Noisy-le-Grand, France) 52, 9-15. PMID: 16914093 2. Hisamatsu, H. et al. (1996) The Journal of experimental medicine 183, 1807-16. PMID: 8666937 3. Greenlund, AC. et al. (1993) The Journal of biological chemistry 268, 18103-10. PMID: 8349687 4. Akiyama, K. et al. (1994) FEBS letters 343, 85-8. PMID: 8163024 5. Fabunmi, RP. et al. (2001) Journal of cell science 114, 29-36. PMID: 11112687 6. Lah, TT. et al. (1995) FEBS letters 363, 85-9. PMID: 7729559
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

Imágenes

SDS-PAGE

SDS-PAGE for Research Grade Emapalumab.
Western blot

Western blot analysis was performed using anti-IFNG/IFN-gamma monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human IFNG/IFN-gamma (Catalog No: HF813012), 50ng
Lane 2: recombinant human IFNG/IFN-gamma (Catalog No: HF813012), 30ng
Lane 3: recombinant human IFNG/IFN-gamma (Catalog No: HF813012), 20ng