Anti-SARS-CoV-2 RBD Reference Antibody (Ensovibep, RUO) (VK565336)

Name: Anti-SARS-CoV-2 RBD Reference Antibody (Ensovibep, RUO)
Brand: abinScience
SKU: VK565336
Price: 370 USD
Availability: InStock

データシート製品共有情報コピー

価格(USD):

スペック:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

数量:

お問い合わせ

概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	VK565336
種反応性	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
アプリケーション	ELISA, Functional assay, Research in vivo
クローン性	Monoclonal
アイソタイプ	DARpin
生物学的活性	BA 1 (0.1 uM) significantly increases FAK tyrosine phosphorylation in BRS-3 transfected NCI-H1299 cells [1].
性質	Recombinant
ターゲット	Spike glycoprotein, Spike, S glycoprotein, RBD
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
精製	Purified by Nickel column.
アクセッション番号	P0DTC2
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	MP0420, D614Gvariant, B.1.351/Beta, P.1/Gamma, B.1.617.2/Delta, AY.2/DeltaPlus, AY.4.2/DeltaPlus, Lambda(C.37), Mu(B.1.621), Omicron(B.1.1.529, BA.1), Omicron(B.1.1.529, BA.2)
背景	Spike glycoprotein (RBD) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293
参考文献	1. Terry W Moody, et al. ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides. 2015 Feb;64:55-61. [VK565336]
注意事項	For research use only. Not suitable for clinical or therapeutic use.