Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO) (HS841016)

Name: Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO)
Brand: abinScience
SKU: HS841016
Price: 176 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HS841016
Description	Erenumab (HS841016) is a research-grade recombinant antibody targeting CGRP type 1 receptor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG2-lambda
Système d'expression	Mammalian cells
Cible	CGRP type 1 receptor, CGRPR, Calcitonin receptor-like receptor, CALCRL, Calcitonin gene-related peptide type 1 receptor
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q16602
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	AMG334, erenumab-aooe, 1582205-90-0
Contexte	Calcitonin gene-related peptide type 1 receptor (CALCRL) is a ~52 kDa protein. G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. 1. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767 2. Josephs, TM. et al. (2021) Science (New York, N.Y.) 372. PMID: 33602864 3. Aiyar, N. et al. (1996) The Journal of biological chemistry 271, 11325-9. PMID: 8626685 4. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Erenumab.
SDS-PAGE

SDS-PAGE for Research Grade Erenumab

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Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO).pdf

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