Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO) (HS841016)

Name: Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO)
Brand: abinScience
SKU: HS841016
Price: 176 USD
Availability: InStock

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概要

カタログ番号	HS841016
説明	Erenumab (HS841016) is a research-grade recombinant antibody targeting CGRP type 1 receptor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG2-lambda
発現システム	Mammalian cells
ターゲット	CGRP type 1 receptor, CGRPR, Calcitonin receptor-like receptor, CALCRL, Calcitonin gene-related peptide type 1 receptor
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q16602
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	AMG334, erenumab-aooe, 1582205-90-0
背景	Calcitonin gene-related peptide type 1 receptor (CALCRL) is a ~52 kDa protein. G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. 1. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767 2. Josephs, TM. et al. (2021) Science (New York, N.Y.) 372. PMID: 33602864 3. Aiyar, N. et al. (1996) The Journal of biological chemistry 271, 11325-9. PMID: 8626685 4. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797
注意事項	For research use only. Not suitable for clinical or therapeutic use.

イメージ

Bioactivity

SEC-HPLC detection for Research Grade Erenumab.
SDS-PAGE

SDS-PAGE for Research Grade Erenumab

参考文献

データシート

Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO).pdf

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Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO) (HS841016)

概要

イメージ

参考文献

データシート

SDS

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