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| カタログ番号 | HB132016 |
|---|---|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2a, kappa |
| 生物学的活性 | Fanolesomab uses a technetium-99m label, enables white blood cell labeling, eliminates need for handling blood products, and is readily available. Fanolesomab exhibits 100% specificity in infection imaging [1]. |
| 発現システム | Mammalian cells |
| ターゲット | Alpha-(1, 3)-fucosyltransferase 4, ELAM-1 ligand fucosyltransferase, Fucosyltransferase 4, Fucosyltransferase IV, Galactoside 3-L-fucosyltransferase, Fuc-TIV, FCT3A, FUT4, ELFT, FucT-IV |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P22083 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Fanolesomab |
| 背景 | Alpha-(1,3)-fucosyltransferase 4 (CD15/SSEA-1) is a ~59 kDa protein. Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. 1. Goelz, SE. et al. (1990) Cell 63, 1349-56. PMID: 1702034 2. Lowe, JB. et al. (1991) The Journal of biological chemistry 266, 17467-77. PMID: 1716630 3. Mondal, N. et al. (2018) The Journal of biological chemistry 293, 7300-7314. PMID: 29593094 4. Nakayama, F. et al. (2001) The Journal of biological chemistry 276, 16100-6. PMID: 11278338 |
| 参考文献 | 1. Klingensmith WC 3rd, et al. Intrapatient comparison of 2-deoxy-2-[F-18]fluoro-D-glucose with positron emissiontomography/computed tomography to Tc-99m fanolesomab (NeutroSpec) for localization of infection. Mol Imaging Biol. 2007;9(5):295-299. [HB132016] |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Fanolesomab.
SDS-PAGE for Research Grade Fanolesomab.
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