Anti-Human IL-17A/F & IL-13 & ALB Multispecific Reference Antibody (Galvokimig, RUO) (HS856206)

Name: Anti-Human IL-17A/F & IL-13 & ALB Multispecific Reference Antibody (Galvokimig, RUO)
Brand: abinScience
SKU: HS856206
Price: 320 USD
Availability: InStock

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概要
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概要

カタログ番号	HS856206
説明	Galvokimig (HS856206) is a research-grade recombinant antibody targeting CTLA-8. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1(VH-CH1-h)-scFv_L-kappa-scFv
テスト済みアプリケーション	WB
ターゲット	CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17, IL17A, Interleukin-17A, ALB, Albumin, IL-13, IL13, Interleukin-13, NC30
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q16552, Q96PD4, P35225, P02768
形態	Liquid
保存バッファー	0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	Trispecific, Trivalent, 2648456-30-6
背景	Interleukin-17A (IL17A/F & IL13 & ALB) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. 1. Boisson, B. et al. (2013) Immunity 39, 676-86. PMID: 24120361 2. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633 3. Wright, JF. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 2799-805. PMID: 18684971 4. Liu, C. et al. (2009) Science signaling 2, ra63. PMID: 19825828 5. Puel, A. et al. (2011) Science (New York, N.Y.) 332, 65-8. PMID: 21350122 6. Fossiez, F. et al. (1996) The Journal of experimental medicine 183, 2593-603. PMID: 8676080
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

イメージ

SDS-PAGE

SDS-PAGE for Research Grade Galvokimig.
Bioactivity

Detects recombinant IL13 (Catalog No: HW632012) in indirect ELISA.
Bioactivity

Detects recombinant human albumin (Catalog No: HY411021) in indirect ELISA.
Western blot

Lane 1: recombinant human IL13 (Catalog No: HW632012)

参考文献

データシート

Anti-Human IL-17A/F & IL-13 & ALB Multispecific Reference Antibody (Galvokimig, RUO).pdf

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Anti-Human IL-17A/F & IL-13 & ALB Multispecific Reference Antibody (Galvokimig, RUO) (HS856206)

概要

イメージ

参考文献

データシート

SDS

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