Anti-Human IL-1 beta/IL-1F2 Reference Antibody (Gevokizumab, RUO) (HF943026)

Name: Anti-Human IL-1 beta/IL-1F2 Reference Antibody (Gevokizumab, RUO)
Brand: abinScience
SKU: HF943026
Price: 176 USD
Availability: InStock

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100ug
1mg
5mg
10mg
25mg
50mg
100mg

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Vista general

Número de catálogo	HF943026
Descripción	Research Grade Gevokizumab (HF943026) is a humanized monoclonal antibody detecting Interleukin-1 beta in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG2-kappa
Sistema de expresión	Mammalian cells
Especies	Human
Aplicaciones probadas	WB
Objetivo	Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P01584
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	XOMA 052, 1129435-60-4
Fondo	Interleukin-1 beta (Interleukin-1 beta,IL1B,Catabolin,IL1F2,IL-1 beta) is a ~30 kDa protein. Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. 1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850 2. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819 3. LaRock, CN. et al. (2016) Science immunology 1. PMID: 28331908 4. Van Damme, J. et al. (1985) Nature 314, 266-8. PMID: 3920526 5. Tian, XX. et al. (2021) International endodontic journal 54, 916-925. PMID: 33377178 6. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10) (HV988107)

Imágenes

SEC-HPLC

SEC-HPLC detection for Research Grade Gevokizumab.
Bioactivity

Detects Human IL1B/IL1F2 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Gevokizumab.
Western blot

Western blot analysis was performed using anti-IL1B/IL1F2 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human IL1B/IL1F2 (Catalog No: HF943012), 50ng
Lane 2: recombinant human IL1B/IL1F2 (Catalog No: HF943012), 30ng
Lane 3: recombinant human IL1B/IL1F2 (Catalog No: HF943012), 20ng
Lane 4: recombinant human IL1B/IL1F2 (Catalog No: HF943012), 10ng