Research Grade Gulgafafusp Alfa (HW328026)

Name: Research Grade Gulgafafusp Alfa
Brand: abinScience
SKU: HW328026
Price: 320 USD
Availability: InStock

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Numéro de catalogue	HW328026
Description	Research Grade Gulgafafusp Alfa (HW328026) is a monoclonal antibody detecting GLP-1R. Expressed in Mammalian cells.
Reactivité des espèces	Human
Applications	ELISA, Functional assay, Research in vivo
Clonalité	Monoclonal
Isotype	human glucagonlike peptide 1 receptor, GLP1R fused at the N-terminus of each light chain (53-266) via the peptide linker 30GSGSATGGSGSGASSGSGSATGS52 to a glucagon-like peptide-1 (GLP-1) fragment
Activité biologique	GLP-1 (7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats [2]. Infusion of GLP-1 (7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM [2].
Système d'expression	Mammalian cells
Nature	Recombinant
Cible	GLP-1 receptor, Glucagon-like peptide 1 receptor, GLP1R, GLP-1-R, GLP-1R, GLP-1(7-36), Incretin hormone, GLP-2, GCG, GLP-1(7-37), OXM, Pro-glucagon, GLP-1, GRPP, OXY
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Purified by Nickel column.
Numéro d'accès	P43220 & P01275
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	2642374-02-3
Contexte	Gulgafafusp alfa is a human IgG2κ antibody targeting the glucagon-like peptide 1 receptor GLP1R.
Reférences	1. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004). [HW328026] 2. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7. [HW328026]
Note	For research use only. Not suitable for clinical or therapeutic use.

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Research Grade Gulgafafusp Alfa (HW328026)

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