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Research Grade Gulgafafusp Alfa
Research Grade Gulgafafusp Alfa
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Спецификация:
  • 100ug
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
Количество:
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  • SDS

Обзор
Каталожный номерHW328026
Описание
Research Grade Gulgafafusp Alfa (HW328026) is a monoclonal antibody detecting GLP-1R. Expressed in Mammalian cells.
Реактивность видовHuman
ПримененияELISA, Functional assay, Research in vivo
КлоональностьMonoclonal
Изотипhuman glucagonlike peptide 1 receptor, GLP1R fused at the N-terminus of each light chain (53-266) via the peptide linker 30GSGSATGGSGSGASSGSGSATGS52 to a glucagon-like peptide-1 (GLP-1) fragment
Биологическая активность GLP-1 (7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats [2]. Infusion of GLP-1 (7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM [2].
Система экспрессии Mammalian cells
Характер Recombinant
Цель GLP-1 receptor, Glucagon-like peptide 1 receptor, GLP1R, GLP-1-R, GLP-1R, GLP-1(7-36), Incretin hormone, GLP-2, GCG, GLP-1(7-37), OXM, Pro-glucagon, GLP-1, GRPP, OXY
Уровень эндотоксинов < 10 EU/mg as determined by LAL method.
Чистота >95% as determined by SDS-PAGE.
Очистка Purified by Nickel column.
Номер доступа P43220 & P01275
Форма Liquid
Буфер хранения 0.01M PBS pH 7.4.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия2642374-02-3
ФонGulgafafusp alfa is a human IgG2κ antibody targeting the glucagon-like peptide 1 receptor GLP1R.
Ссылки 1. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004). [HW328026]
2. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7. [HW328026]
Примечание For research use only. Not suitable for clinical or therapeutic use.
Изображения
  • Research Grade Gulgafafusp Alfa

    SDS-PAGE

    SDS-PAGE for Research Grade Gulgafafusp Alfa.

Ссылки
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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