

| Каталожный номер | HW328026 |
|---|---|
| Описание |
Research Grade Gulgafafusp Alfa (HW328026) is a monoclonal antibody detecting GLP-1R. Expressed in Mammalian cells.
|
| Реактивность видов | Human |
| Применения | ELISA, Functional assay, Research in vivo |
| Клоональность | Monoclonal |
| Изотип | human glucagonlike peptide 1 receptor, GLP1R fused at the N-terminus of each light chain (53-266) via the peptide linker 30GSGSATGGSGSGASSGSGSATGS52 to a glucagon-like peptide-1 (GLP-1) fragment |
| Биологическая активность | GLP-1 (7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats [2]. Infusion of GLP-1 (7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM [2]. |
| Система экспрессии | Mammalian cells |
| Характер | Recombinant |
| Цель | GLP-1 receptor, Glucagon-like peptide 1 receptor, GLP1R, GLP-1-R, GLP-1R, GLP-1(7-36), Incretin hormone, GLP-2, GCG, GLP-1(7-37), OXM, Pro-glucagon, GLP-1, GRPP, OXY |
| Уровень эндотоксинов | < 10 EU/mg as determined by LAL method. |
| Чистота | >95% as determined by SDS-PAGE. |
| Очистка | Purified by Nickel column. |
| Номер доступа | P43220 & P01275 |
| Форма | Liquid |
| Буфер хранения | 0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Альтернативные названия | 2642374-02-3 |
| Фон | Gulgafafusp alfa is a human IgG2κ antibody targeting the glucagon-like peptide 1 receptor GLP1R. |
| Ссылки | 1. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004). [HW328026] 2. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7. [HW328026] |
| Примечание | For research use only. Not suitable for clinical or therapeutic use. |

SDS-PAGE for Research Grade Gulgafafusp Alfa.
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