Anti-Human FCRN/FCGRT Reference Antibody (Imeroprubart, RUO) (HX061086)

Name: Anti-Human FCRN/FCGRT Reference Antibody (Imeroprubart, RUO)
Brand: abinScience
SKU: HX061086
Price: 176 USD
Availability: InStock

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100ug
1mg
5mg
10mg
25mg
50mg
100mg

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Каталожный номер	HX061086
Описание	imeroprubart (HX061086) is a research-grade recombinant antibody targeting FCGRT/FCRN. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1, lambda2
Виды	Human
Цель	FCGRT/FCRN
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Номер доступа	P55899
Форма	Liquid
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	2894136-80-0
Фон	IgG receptor FcRn large subunit p51 (FCGRT) is a ~39 kDa protein. Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. 1. West, AP. et al. (2000) Biochemistry 39, 9698-708. PMID: 10933786 2. Story, CM. et al. (1994) The Journal of experimental medicine 180, 2377-81. PMID: 7964511 3. Mikulska, JE. et al. (2000) European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 27, 231-40. PMID: 10998088 4. Oganesyan, V. et al. (2014) The Journal of biological chemistry 289, 7812-24. PMID: 24469444 5. Pyzik, M. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2862-E2871. PMID: 28330995
Примечание	For research use only. Not suitable for clinical or therapeutic use.