Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO) (HF004206)

Name: Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO)
Brand: abinScience
SKU: HF004206
Price: 400 USD
Availability: InStock

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100ug
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5mg
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SDS

Vista general

Número de catálogo	HF004206
Descripción	Izalontamab (HF004206) is a research-grade recombinant antibody targeting HER1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-kappa-[scFv-heavy-lambda]2
Aplicaciones probadas	FCM
Objetivo	EC:2.7.10.1, EGFR, ERBB, ERBB1, Epidermal growth factor receptor, HER1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EC:2.7.10.1, ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P00533 & P21860
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	Tetravalentbispecific, SI-1, SI-1X6.4, SI-B001, 2559704-24-2
Fondo	Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer.
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Imágenes

Bioactivity

Detects EGFR in indirect ELISA.
Flow cytometry

Flow-cytometry using anti-human ERBB3 antibody. HepG2 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ERBB3 monoclonal antibody (Catalog HF004206, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.

Referencias

Datasheet

Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Proteínas Recombinantes

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