Anti-Human FOLR1 Reference Antibody (Lazatatug, RUO) (HB825076)

Name: Anti-Human FOLR1 Reference Antibody (Lazatatug, RUO)
Brand: abinScience
SKU: HB825076
Price: 370 USD
Availability: InStock

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Numéro de catalogue	HB825076
Description	lazatatug (HB825076) is a research-grade recombinant antibody targeting FOLR1. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Reactivité des espèces	Human
Applications	ELISA, FACS, Functional assay
Espèce hôte	Human
Isotype	IgE, kappa
Cible	FOLR1
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE
Numéro d'accès	P15328
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CAS: 3035565-36-4
Contexte	Folate receptor alpha is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. 1. Zhao, R. et al. (2009) The Journal of biological chemistry 284, 4267-74. PMID: 19074442 2. Chen, C. et al. (2013) Nature 500, 486-9. PMID: 23851396 3. Wibowo, AS. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15180-8. PMID: 23934049 4. Lacey, SW. et al. (1989) The Journal of clinical investigation 84, 715-20. PMID: 2527252 5. Orr, RB. et al. (1994) Cancer research 54, 3905-11. PMID: 8033114 6. Rijnboutt, S. et al. (1996) The Journal of cell biology 132, 35-47. PMID: 8567728
Note	For research use only.