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| カタログ番号 | HV345026 | ||||
|---|---|---|---|---|---|
| 説明 |
Research Grade lexucitug (HV345026) is a human monoclonal antibody. Suitable for Human.
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| 種反応性 | Human | ||||
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1, kappa | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9NPY3 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Complement component C1q receptor (CD93/C1qR) is a ~68 kDa protein. Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. 1. Geertsma, MF. et al. (1994) The American journal of physiology 267, L578-84. PMID: 7977768 2. Orlandini, M. et al. (2014) Oncotarget 5, 2750-60. PMID: 24809468 3. Galvagni, F. et al. (2016) Oncotarget 7, 10090-103. PMID: 26848865 4. Khan, KA. et al. (2017) Oncogene 36, 6097-6108. PMID: 28671670 5. Barbera, S. et al. (2023) International journal of biological macromolecules 224, 453-464. PMID: 36265539 6. Xu, Y. et al. (2024) Structure (London, England : 1993) 32, 282-291.e4. PMID: 38218180 | ||||
| 注意事項 | For research use only. |
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