Anti-Human TCR alpha Reference Antibody (Maslimomab, RUO) (HF009016)

Name: Anti-Human TCR alpha Reference Antibody (Maslimomab, RUO)
Brand: abinScience
SKU: HF009016
Price: 176 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HF009016
説明	Maslimomab (HF009016) is a research-grade recombinant antibody targeting T cell receptor alpha chain constant. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG2b-nd
発現システム	Mammalian cells
ターゲット	T cell receptor alpha chain constant, TRAC, TCRA
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P01848
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	127757-92-0
背景	T cell receptor alpha chain constant (TRAC) is a ~15 kDa protein. Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. 1. Lefranc, MP. (2014) Frontiers in immunology 5, 22. PMID: 24600447 2. Rossjohn, J. et al. (2015) Annual review of immunology 33, 169-200. PMID: 25493333 3. Brownlie, RJ. et al. (2013) Nature reviews. Immunology 13, 257-69. PMID: 23524462 4. Nikolich-Zugich, J. et al. (2004) Nature reviews. Immunology 4, 123-32. PMID: 15040585
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2b, kappa Recombinant Isotype Control Antibody (MPC-11) (MF974207)