Anti-Human LILRB2/CD85d/ILT4 Reference Antibody (Mk-4830, RUO) (HV255026)

Name: Anti-Human LILRB2/CD85d/ILT4 Reference Antibody (Mk-4830, RUO)
Brand: abinScience
SKU: HV255026
Price: 326 USD
Availability: InStock

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Número de catálogo	HV255026
Descripción	MK-4830 (HV255026) is a research-grade recombinant antibody targeting CD85. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG4-lambda
Sistema de expresión	Mammalian cells
Objetivo	CD85 antigen-like family member D, Monocyte/macrophage immunoglobulin-like receptor 10, MIR-10, ILT4, LIR-2, ILT-4, Immunoglobulin-like transcript 4, MIR10, CD85d, Leukocyte immunoglobulin-like receptor subfamily B member 2, Leukocyte immunoglobulin-like receptor 2, LIR2, LILRB2
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q8N423
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Leukocyte immunoglobulin-like receptor subfamily B member 2 (CD85d/LILRB2) is a ~65 kDa protein. Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. 1. Lepin, EJ. et al. (2000) European journal of immunology 30, 3552-61. PMID: 11169396 2. Shiroishi, M. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 8856-61. PMID: 12853576 3. Shiroishi, M. et al. (2006) The Journal of biological chemistry 281, 10439-47. PMID: 16455647 4. Gregori, S. et al. (2010) Blood 116, 935-44. PMID: 20448110 5. Köstlin, N. et al. (2017) European journal of immunology 47, 374-384. PMID: 27859042 6. Chang, CC. et al. (2002) Nature immunology 3, 237-43. PMID: 11875462 8. Fanger, NA. et al. (1998) European journal of immunology 28, 3423-34. PMID: 9842885
Nota	For research use only. Not suitable for clinical or therapeutic use.