Anti-Human IL-17C Reference Antibody (Mor106, RUO) (HV335026)

Name: Anti-Human IL-17C Reference Antibody (Mor106, RUO)
Brand: abinScience
SKU: HV335026
Price: 370 USD
Availability: InStock

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100ug
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Reférences
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SDS

Aperçu

Numéro de catalogue

HV335026

Description

MOR106 (HV335026) is a research-grade recombinant antibody targeting Cytokine CX2.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.

Reactivité des espèces

Human

Applications

ELISA, FACS, Functional assay

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG1, kappa

Cible

Cytokine CX2, IL-17C, IL17C, Interleukin-17C

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q9P0M4

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Interleukin-17C (IL17C) is a ~21 kDa protein. Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype.

Note

For research use only.

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