Anti-Human GDNF Reference Antibody (Nadecnemab, RUO) (HT009016)

Name: Anti-Human GDNF Reference Antibody (Nadecnemab, RUO)
Brand: abinScience
SKU: HT009016
Price: 176 USD
Availability: InStock

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Referencias
Datasheet
SDS

Vista general

Número de catálogo	HT009016
Descripción	Nadecnemab (HT009016) is a research-grade recombinant antibody targeting GFR-alpha-3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG4-Kappa
Sistema de expresión	Mammalian cells
Objetivo	GFR-alpha-3, GDNF receptor alpha-3, GDNF family receptor alpha-3, GDNFR-alpha-3, GFRA3
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	O60609
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	REGN5069, 2377679-19-9
Fondo	GDNF family receptor alpha-3 (GFRA3) is a ~44 kDa protein. Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor. 1. Li, J. et al. (2019) eLife 8. PMID: 31535977 2. Baloh, RH. et al. (1998) Neuron 21, 1291-302. PMID: 9883723
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)

Imágenes

SEC-HPLC

SEC-HPLC detection for Research Grade Nadecnemab.
Bioactivity

Detects GFRA3 in indirect ELISAs.

Referencias

Datasheet

Anti-Human GDNF Reference Antibody (Nadecnemab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Working Solution

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Proteínas Recombinantes

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