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Anti-Human IL-31RA Reference Antibody (Nolavetbart, RUO) (CV121016)

Anti-Human IL-31RA Reference Antibody (Nolavetbart, RUO)
Anti-Human IL-31RA Reference Antibody (Nolavetbart, RUO)
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Aperçu
Numéro de catalogueCV121016
Description
Nolavetbart (CV121016) is a research-grade recombinant antibody targeting IL31RA. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espècesCanine
ApplicationsELISA, Bioactivity: FCM, Functional assay, Research in vivo
Espèce hôteCanine
ClonalitéMonoclonal
IsotypeIgG2-kappa
Système d'expression Mammalian cells
Nature Recombinant
Cible IL31RA
Niveau d'endotoxines < 10 EU/mg as determined by LAL method.
Pureté >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Numéro d'accès A0A8I3Q391
Forme Liquid
Tampon de stockage 0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs2750248-93-0
Contexte

Interleukin-31 receptor subunit alpha (IL31RA) is a ~82 kDa protein. Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.

1. Ghilardi, N. et al. (2002) The Journal of biological chemistry 277, 16831-6. PMID: 11877449
2. Diveu, C. et al. (2003) The Journal of biological chemistry 278, 49850-9. PMID: 14504285
3. Dreuw, A. et al. (2004) The Journal of biological chemistry 279, 36112-20. PMID: 15194700
4. Diveu, C. et al. (2004) European cytokine network 15, 291-302. PMID: 15627637
5. Dillon, SR. et al. (2004) Nature immunology 5, 752-60. PMID: 15184896
Note For research use only. Not suitable for clinical or therapeutic use.
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  • Anti-Human IL-31RA Reference Antibody (Nolavetbart, RUO)

    SDS-PAGE

    SDS-PAGE for Research Grade Nolavetbart

Reférences
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Recommandation

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