Anti-Human Endosialin/CD248 Reference Antibody (Ontuxizumab, RUO) (HV681016)

Name: Anti-Human Endosialin/CD248 Reference Antibody (Ontuxizumab, RUO)
Brand: abinScience
SKU: HV681016
Price: 176 USD
Availability: InStock

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100ug
1mg
5mg
10mg
25mg
50mg
100mg

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Referencias
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SDS

Vista general

Número de catálogo	HV681016
Descripción	Ontuxizumab (HV681016) is a research-grade recombinant antibody targeting CD164L. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-kappa
Sistema de expresión	Mammalian cells
Objetivo	Endosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q9HCU0
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	MORAb-004, 946415-62-9
Fondo	Endosialin (CD248) is a ~80 kDa protein. Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory response in macrophages by favoring the production of proinflammatory cytokines. 1. Tomkowicz, B. et al. (2010) Cancer biology & therapy 9, 908-15. PMID: 20484976 2. Hardie, DL. et al. (2011) Immunology 133, 288-95. PMID: 21466550
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)

Imágenes

Bioactivity

SEC-HPLC detection for Research Grade Ontuxizumab.
SDS-PAGE

SDS-PAGE for Research Grade Ontuxizumab

Referencias

Datasheet

Anti-Human Endosialin/CD248 Reference Antibody (Ontuxizumab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

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Volume

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g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

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Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

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