Anti-Human FOLR1 Reference Antibody (Onvontatug, RUO) (HB825086)

Name: Anti-Human FOLR1 Reference Antibody (Onvontatug, RUO)
Brand: abinScience
SKU: HB825086
Price: 370 USD
Availability: InStock

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100ug
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Aperçu

Numéro de catalogue

HB825086

Description

Research Grade onvontatug (HB825086) is a human monoclonal antibody. Suitable for Human.

Reactivité des espèces

Human

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG1, kappa

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P15328

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere).

1. Zhao, R. et al. (2009) The Journal of biological chemistry 284, 4267-74. PMID: 19074442

2. Chen, C. et al. (2013) Nature 500, 486-9. PMID: 23851396

3. Wibowo, AS. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15180-8. PMID: 23934049

4. Lacey, SW. et al. (1989) The Journal of clinical investigation 84, 715-20. PMID: 2527252

5. Orr, RB. et al. (1994) Cancer research 54, 3905-11. PMID: 8033114

6. Rijnboutt, S. et al. (1996) The Journal of cell biology 132, 35-47. PMID: 8567728

Note

For research use only.

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