Anti-Human CD37 Reference Antibody (Otlertuzumab, RUO) (HY564036)

Name: Anti-Human CD37 Reference Antibody (Otlertuzumab, RUO)
Brand: abinScience
SKU: HY564036
Price: 176 USD
Availability: InStock

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100ug
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5mg
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Número de catálogo	HY564036
Descripción	Otlertuzumab (HY564036) is a research-grade recombinant antibody targeting CD37. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	VH-V-kappa-CH2-CH3
Sistema de expresión	Mammalian cells
Naturaleza	Recombinant
Aplicaciones probadas	FCM
Objetivo	CD37, Tspan-26, TSPAN26, Leukocyte antigen CD37, Tetraspanin-26
Nivel de endotoxinas	< 10 EU/mg as determined by LAL method.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P11049
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	TRU-016, 1372645-37-8
Fondo	Leukocyte antigen CD37 (TSPAN26) is a ~31 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. 1. Lapalombella, R. et al. (2012) Cancer cell 21, 694-708. PMID: 22624718 2. de Winde, CM. et al. (2016) The Journal of clinical investigation 126, 653-66. PMID: 26784544 3. Meyer-Wentrup, F. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 154-62. PMID: 17182550
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Imágenes

Flow CytoMetry

Flow-cytometry using FITC anti-human CD37 antibody. Raji cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human CD37 monoclonal antibody (Catalog: HY564036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE

SDS-PAGE for Research Grade Otlertuzumab

Referencias

Datasheet

Anti-Human CD37 Reference Antibody (Otlertuzumab, RUO).pdf

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Anti-Human CD37 Reference Antibody (Otlertuzumab, RUO) (HY564036)

Vista general

Imágenes

Referencias

Datasheet

SDS