Anti-Human Transferrin R/TfR Reference Antibody (Pabinafusp Alfa, RUO) (HY036016)

Name: Anti-Human Transferrin R/TfR Reference Antibody (Pabinafusp Alfa, RUO)
Brand: abinScience
SKU: HY036016
Price: 482 USD
Availability: InStock

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100ug
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SDS

Vista general

Número de catálogo	HY036016
Descripción	Pabinafusp Alfa (HY036016) is a research-grade recombinant antibody targeting CD71. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-kappa
Aplicaciones probadas	WB
Objetivo	CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17, IL17A, Interleukin-17A, ALB, Albumin, IL-13, IL13, Interleukin-13, NC30
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P02786
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	JR-141, 2140211-48-7
Fondo	Transferrin receptor protein 1 (CD71/TFRC & IDS) is a ~84 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. 1. Senyilmaz, D. et al. (2015) Nature 525, 124-8. PMID: 26214738 2. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 26642240
Nota	For research use only. Not suitable for clinical or therapeutic use.

Imágenes

Bioactivity

Detects CD71/TFRC in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-CD71/TFRC monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD71/TFRC (Catalog No: HY036011)
Lane 2: negative control